Reward Processing by the Opioid System in the Brain
نویسندگان
چکیده
منابع مشابه
Reward processing by the opioid system in the brain.
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechani...
متن کاملReward Processing by the Opioid System in the Brain
A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towar...
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μ-opioid receptor system mediates reward processing in humans
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [11C]carfentanil. During a functional magnetic resonance imaging...
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BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" ...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2009
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00005.2009